| Identification | Back Directory | [Name]
O-GLYCOSIDASE | [CAS]
9032-92-2 | [Synonyms]
EC 3.2.1.97
O-Glycanase
O-GLYCOSIDASE
O-GLYCAN PEPTIDE HYDROLASE
endo-α-n-acetylgalactosaminidase
O-GLYCOSIDASE, EXPRESSED IN E. COLI
ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE
o-glycosidase from streptococcus pneumoniae
Endo-α-N-acetylgalactosaminidase, O-Glycanase
O-Glycosidase from Streptococcus pneumoniae, Recombinant
ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE, STREPTOCOCCUS PNEUMONIAE
O-GLYCOPEPTIDE ENDO-D-GALACTOSYL-N-ACETYL-ALPHA-GALACTOSAMINOHYDROLASE | [EINECS(EC#)]
232-888-2 | [MDL Number]
MFCD00131003 |
| Hazard Information | Back Directory | [Uses]
O-Glycosidase is used to release the Gal-β(1,3)-GaINAc unit from O-glycans (glycoproteins or glycopeptides). Bindings to serine as well as to threonine are hydrolyzed. Substituents at the disaccharide (e.g., sialic acid) prevent the hydrolysis and, therefore, have to be removed chemically or enzymatically (e.g., with neuraminidase from Arthrobacter or from Vibrio cholerae).
O-Glycosidase has been used to selectively deglycosylated chondroitin sulfate proteoglycans (CSPGs). | [General Description]
O-Glycan-peptide hydrolase
O-Glycopeptide endo-D-galactosyl-N-acetyl-α-galactosamino hydrolase
O-Glycosidase is isolated from the culture filtrate of Diplococcus pneumoniae | [Biochem/physiol Actions]
Releases unsubstituted Ser- and Thr-linked β-Gal-(1→3)-α-GalNAc (Core 1 type O-glycan) from glycoproteins. Substitutions of the disaccharide core with sialic acid, lactosamine (galactose-N-acetyl glucosamine), or fucose will block hydrolysis and prevent the liberation of the oligosaccharide from the protein. Pretreament with glycolytic enzymes to remove substituent saccharides from the O-glycan may be needed prior to cleavage using O-glycosidase.. |
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