| Identification | Back Directory | [Name]
PE(22:1(13E)/22:1(13E)) | [CAS]
904304-57-0 | [Synonyms]
thanolamine
PE(22:1(13E)/22:1(13E))
Dierucoyl phosphatidylethanolamine
1,2-DIERUCOYL-SN-GLYCERO-3-PHOSPHOET
1,2-Dierucoyl-sn-glycero-3-phosph&&oelig
1,2-Dierucoyl-sn-glycero-3-phosphoethanolamine
1,2-Di(cis-13-docosenoyl)-sn-glycero-3-phosphoethanolamine
1,2-Dierucoyl-sn-glycero-3-phosphoethanolamine >=98% (TLC)
1,2-Dichloro-sn-glycerol-3-phosphatidylethanolamine (PE (22:1 (13E)/22:1 (13E))
13-Docosenoic acid, 1,1'-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester, (13Z,13'Z)- | [Molecular Formula]
C49H94NO8P | [MDL Number]
MFCD16872052 | [MOL File]
904304-57-0.mol | [Molecular Weight]
856.25 |
| Chemical Properties | Back Directory | [Boiling point ]
828.6±75.0 °C(Predicted) | [density ]
0.984±0.06 g/cm3(Predicted) | [Fp ]
>200℃ | [storage temp. ]
-20°C | [solubility ]
Methanol: Slightly Soluble: 0.1-1 mg/ml | [form ]
powder | [pka]
1.17±0.50(Predicted) |
| Hazard Information | Back Directory | [Description]
1,2-Dierucoyl->sn-glycero-3-PE is a phospholipid containing erucic acid (13(Z)-docosenoic acid; Item No. 90175) at the sn-1 and sn-2 positions. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 1,2-Dierucoyl-sn-glycero-3-PE has also been used in the synthesis of various PEG-conjugates for incorporation into liposomes.2,3,4 LNPs containing 1,2-dierucoyl-sn-glycero-3-PE and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.1WARNING This product is not for human or veterinary use. | [References]
[1] AMITA VAIDYA, FRANK DEROSA Analytical Characterization of Heterogeneities in mRNA-Lipid Nanoparticles Using Sucrose Density Gradient Ultracentrifugation[J]. Analytical Chemistry, 2024, 96 14: 5570-5579. DOI: 10.1021/acs.analchem.4c00031
[2] KENNETH J LONGMUIR. Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence.[J]. Pharmaceutical Research, 2006, 23 4: 759-769. DOI: 10.1007/s11095-006-9609-x
[3] SHERRY M HAYNES. Liposomal polyethyleneglycol and polyethyleneglycol-peptide combinations for active targeting to liver in vivo.[J]. Drug Delivery, 2008, 15 4: 207-217. DOI: 10.1080/10717540802006211
[4] MONICA S TSAI. Binding patterns of peptide-containing liposomes in liver and spleen of developing mice: comparison with heparan sulfate immunoreactivity.[J]. Journal of Drug Targeting, 2011, 19 7: 506-515. DOI: 10.3109/1061186x.2010.511227 |
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