| Identification | Back Directory | [Name]
Carbamic acid, N-cyclohexyl-, 6-hydroxy[1,1'-biphenyl]-3-yl ester | [CAS]
904672-77-1 | [Synonyms]
URB694
Carbamic acid, N-cyclohexyl-, 6-hydroxy[1,1'-biphenyl]-3-yl ester | [Molecular Formula]
C19H21NO3 | [MOL File]
904672-77-1.mol | [Molecular Weight]
311.37 |
| Chemical Properties | Back Directory | [Melting point ]
118-119 °C(Solv: dichloromethane (75-09-2); ligroine (8032-32-4)) | [Boiling point ]
474.3±45.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [pka]
9?+-.0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2]. | [in vivo]
URB694 (0.3 mg/kg; i.p.) increases the time spent by HAB rats on the open arms compared to vehicle condition, without affecting overall locomotor activity[1].
URB694 (0.3 mg/kg; i.p.) reduces isoproterenol hydrochloride (ISOP; HY-B0468)-induced arrhythmia occurrence in HAB rats, whereas it has no significant effects in NAB and LAB rats[1]. | Animal Model: | 5-month-old male Wistar rats (350-450?g) selectively bred for high (HAB) and low (LAB) anxiety-related behavior in the elevated plus-maze test or non-selected rats (NAB)[1] | | Dosage: | 0.3 mg/kg | | Administration: | Administered intraperitoneally to rats in a volume of 0.5?mL/kg | | Result: | Significantly increased the time spent by HAB rats on the open arms.
Had no effects on NABs’ and LABs’ behavioral performance in the elevated plus maze test.
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| Animal Model: | HAB, NAB and LAB rats[1] | | Dosage: | 0.3 mg/kg | | Administration: | Received the i.p. injection 30 min before ISOP (0.02?mg/kg) | | Result: | Significantly reduced ISOP-induced arrhythmia occurrence in HAB rats compared to vehicle pretreatment condition.
Had no significant effects in NAB and LAB rats.
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| [References]
[1] Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218. DOI:10.1038/srep18218
[2] Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55(12):1993-7. DOI:10.2967/jnumed.114.146464 |
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