| Identification | Back Directory | [Name]
3-METHOXY-5-METHYLBENZALDEHYDE | [CAS]
90674-26-3 | [Synonyms]
3-METHOXY-5-METHYLBENZALDEHYDE
Benzaldehyde, 3-methoxy-5-methyl- | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD11046639 | [MOL File]
90674-26-3.mol | [Molecular Weight]
150.17 |
| Chemical Properties | Back Directory | [Boiling point ]
85 °C(Press: 2 Torr) | [density ]
1.062±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
B) Synthesis of 3-methoxy-5-methylbenzaldehyde: 2-Iodobenzoic acid (4.00 g) was added to a solution of (3-methoxy-5-methylphenyl) methanol (2.20 g) in DMSO (15 mL) at 0 °C and the reaction mixture was stirred. The reaction system was then warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, ethyl acetate (50 mL) and water (10 mL) were added to the mixture and the insoluble material was removed by filtration. The organic phase was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product 3-methoxy-5-methylbenzaldehyde (2.00 g) as a yellow oil, which could be used for subsequent reactions without further purification. | [References]
[1] Journal of the American Chemical Society, 2012, vol. 134, # 30, p. 12402 - 12405
[2] Synthesis, 2007, # 1, p. 65 - 74
[3] Tetrahedron Letters, 1996, vol. 37, # 49, p. 8953 - 8956
[4] European Journal of Organic Chemistry, 2001, # 1, p. 163 - 171
[5] Journal of the American Chemical Society, 2011, vol. 133, # 39, p. 15686 - 15696 |
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