| Identification | Back Directory | [Name]
NSC 105327 | [CAS]
906748-38-7 | [Synonyms]
Z-INDIRUBIN
Z-INDIRUBIN-D8
(2′Z)-Indirubin
(2'Z)-Indirubin >=98% (HPLC)
(Z)-[2,3’-Biindolinylidene]-2’,3-dione
(Z)-[2,3’-Biindolinylidene]-2’,3-dione
[Δ2,3′-Biindoline]-2′,3-dione (7CI,8CI)
3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one
2H-Indol-2-one, 3-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-, (3Z)-
(Z)-[2,3-biindolinylidene]-2,3-dione/(3Z)-3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one | [Molecular Formula]
C16H10N2O2 | [MDL Number]
MFCD00956441 | [MOL File]
906748-38-7.mol | [Molecular Weight]
262.26 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble2mg/mL, clear (warmed) | [form ]
powder | [InChI]
1S/C16H10N2O2/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20/h1-8,17H,(H,18,20)/b14-13- | [InChIKey]
CRDNMYFJWFXOCH-YPKPFQOOSA-N | [SMILES]
O=C1Nc2ccccc2\C1=C3\Nc4ccccc4C3=O |
| Hazard Information | Back Directory | [Uses]
(Z)-Indirubin-d4 is the deuterium labeled (Z)-Indirubin[1]. | [Biochem/physiol Actions]
Indirubin is an inhibitor of GSK-3β and of cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110 |
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