| Identification | Back Directory | [Name]
8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione | [CAS]
90749-32-9 | [Synonyms]
8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
8-[2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl]-3,7-dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
1H-Purine-2,6-dione, 8-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]-3,9-dihydro-1-methyl-3-(2-methylpropyl)- | [Molecular Formula]
C29H36N6O2 | [MOL File]
90749-32-9.mol | [Molecular Weight]
500.64 |
| Chemical Properties | Back Directory | [Melting point ]
202 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
692.5±65.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [pka]
8.99±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM)[1]. | [in vivo]
In male Sprague Dawley rats, Laprafylline (S 9795; 2.5-10mg/kg; iv) disappears rapidly from plasma with an elimination t1/2 of 0.8 h, regardless of the dose administered. The volume of distribution is high (about 3 L/kg) but total clearance is also high (about 40 mL/min/kg). | [References]
[1] G Bianchi, et al. Kinetics and brain uptake of S 9795, a new xanthine derivate, in rats. Eur J Drug Metab Pharmacokinet. 1989 Jul-Sep;14(3):201-8. DOI:10.1007/BF03190100 |
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