| Identification | Back Directory | [Name]
SNX-7081 | [CAS]
908111-22-8 | [Synonyms]
SNX-7081
Benzamide, 2-[(trans-4-hydroxycyclohexyl)amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indol-1-yl)- | [Molecular Formula]
C24H31N3O3 | [MOL File]
908111-22-8.mol | [Molecular Weight]
409.52 |
| Hazard Information | Back Directory | [Description]
NX-7081 is a novel small molecule inhibitor of Hsp90, which blocks components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp70. NF-kappaB nuclear translocation was blocked by SNX-7081 at nanomolar concentrations, and cytokine production was potently inhibited. Growth factor activation of ERK and JNK signaling was significantly reduced by SNX-7081. NO production was also sharply inhibited. In animal models, SNX-4414 fully inhibited paw swelling and improved body weight. |
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