| Identification | Back Directory | [Name]
OPIPRAMOL DIHYDROCHLORIDE | [CAS]
909-39-7 | [Synonyms]
ensidon
insidondihydrochloride
opipramolhydrochloride
Opipramol dihydrochloride >=98% (HPLC), solid
4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride
4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride
4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadiclori
5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc
Opipramol DihydrochlorideQ: What is
Opipramol Dihydrochloride Q: What is the CAS Number of
Opipramol Dihydrochloride Q: What is the storage condition of
Opipramol Dihydrochloride | [EINECS(EC#)]
213-000-2 | [Molecular Formula]
C23H31Cl2N3O | [MDL Number]
MFCD00941483 | [MOL File]
909-39-7.mol | [Molecular Weight]
436.418 |
| Chemical Properties | Back Directory | [Melting point ]
210° (FR M209); mp 228-230° (DE 1133729) | [solubility ]
H2O: ~24 mg/mL | [form ]
solid | [color ]
yellow | [Water Solubility ]
H2O: ~24mg/mL | [InChI]
1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H | [InChIKey]
DLTOEESOSYKJBK-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
22-50/53 | [Safety Statements ]
60-61 | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [RTECS ]
TL9100000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| Hazard Information | Back Directory | [Originator]
Insidon,Geigy,W. Germany,1962 | [Uses]
antidepressant, antipsychotic;'sigma antagonist | [Manufacturing Process]
A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C. | [Therapeutic Function]
Antidepressant, Antipsychotic | [Biological Activity]
δ1/δ2 opioid receptor agonist; an antagonist at D25HT2 and H1 receptors; atypical antidepressantantipsychotic and anxiolytic |
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Ralington Pharma
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Alfa Chemistry
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Energy Chemical
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Merck KGaA
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