| Identification | Back Directory | [Name]
(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt) | [CAS]
909725-64-0 | [Synonyms]
W140
(S)-3-aMino-4-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
(S)-3-AMINO-4-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W140 | [Molecular Formula]
C18H28F3N2O6P | [MOL File]
909725-64-0.mol | [Molecular Weight]
456.4 |
| Hazard Information | Back Directory | [Description]
W140 is the inactive enantiomer of the sphingosine-1-phosphate receptor 1 (S1P1) antagonist W146 .1 It only weakly binds to S1P1 (Ki = 4.6 μM for the human receptor). W140 has been used as a negative control in vitro and in vivo in the study of S1P1 signaling.1,2 | [Uses]
W140 (TFA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [References]
1. Sanna, M.G., Wang, S.K., Gonzalez-Cabrera, P.J., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo Nat. Chem. Biol. 2(8),434-441(2006).
2. Li, C., Chi, X.X., Xie, W., et al. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J. Neurophysiol. 108(5),1473-1483(2012). |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
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