| Identification | Back Directory | [Name]
2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5,8a-dimethyl-2-methylene-5-[(triphenylmethoxy)methyl]-1-naphthalenyl]ethenyl]- | [CAS]
910582-16-0 | [Synonyms]
ZIKV-IN-2
2(5H)-Furanone, 3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5,8a-dimethyl-2-methylene-5-[(triphenylmethoxy)methyl]-1-naphthalenyl]ethenyl]- | [Molecular Formula]
C39H42O4 | [MOL File]
910582-16-0.mol | [Molecular Weight]
574.75 |
| Hazard Information | Back Directory | [Uses]
ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV)[1]. | [References]
[1] Qian W, et al. Discovery of dehydroandrographolide derivatives with C19 hindered ether as potent anti-ZIKV agents with inhibitory activities to MTase of ZIKV NS5. Eur J Med Chem. 2022 Aug 27;243:114710. DOI:10.1016/j.ejmech.2022.114710 |
|
|