| Identification | Back Directory | [Name]
etonitazene | [CAS]
911-65-9 | [Synonyms]
ARC-1G-2
NIH-7607
etonitazene
Etonitazine
Ciba-20684BA
2-[2-(4-ethoxybenzyl)-5-nitro-benzimidazol-1-yl]ethyl-diethyl-amine
1-[2-(Diethylamino)ethyl]-2-(p-ethoxybenzyl)-5-nitro-1H-benzimidazole
2-[2-[(4-ethoxyphenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
2-(2-(4-ethoxybenzyl)-5-nitro-1H-benzo[d]imidazol-1-yl)-N,N-diethylethanamine
1H-Benzimidazole-1-ethanamine, 2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-5-nitro-
2-[2-[(4-ethoxyphenyl)methyl]-5-nitro-benzimidazol-1-yl]-N,N-diethyl-ethanamine | [EINECS(EC#)]
213-009-1 | [Molecular Formula]
C22H28N4O3 | [MOL File]
911-65-9.mol | [Molecular Weight]
396.48 |
| Chemical Properties | Back Directory | [Boiling point ]
580.7±45.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [solubility ]
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
9.90±0.25(Predicted) |
| Hazard Information | Back Directory | [Description]
Etonitazene (Item No. 21824) is an analytical reference standard categorized as an opioid. Etonitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications. | [Uses]
Etonitazene-d5 is the isotope labelled analog of Etonitazene (E933600); a μ-opioid receptor agonist structurally related to Clonitazene (C587135). | [References]
[1] PETER BLANCKAERT. Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene[J]. Drug Testing and Analysis, 2019, 12 4: 422-430. DOI: 10.1002/dta.2738
[2] MARJORIE S. MOOLTEN. Etonitazene: An opioid selective for the mu receptor types[J]. Life sciences, 1993, 52 18: Pages PL199-PL203. DOI: 10.1016/0024-3205(93)90118-m
[3] MARTHE M. VANDEPUTTE. Synthesis, Chemical Characterization, and μ-Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2-Benzylbenzimidazole Synthetic Opioids.[J]. ACS Chemical Neuroscience, 2021. DOI: 10.22541/au.160520665.59016513/v2
[4] ISTVáN UJVáRY*. DARK Classics in Chemical Neuroscience: Etonitazene and Related Benzimidazoles[J]. ACS Chemical Neuroscience, 2021, 12 7: 1072-1092. DOI: 10.1021/acschemneuro.1c00037
[5] MENG-HUA M. TSAI, LEI SHI* In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling[J]. ACS Chemical Neuroscience, 2024, 15 4: 854-867. DOI: 10.1021/acschemneuro.3c00750
[6] GRANT C GLATFELTER. Alkoxy chain length governs the potency of 2-benzylbenzimidazole “nitazene” opioids associated with human overdose.[J]. Psychopharmacology, 2023: 2573-2584. DOI: 10.1007/s00213-023-06451-2 |
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