| Hazard Information | Back Directory | [Description]
RO4988546 is a potent mGlu?/? negative allosteric modulator. | [Uses]
RO4988546 is a negative allosteric modulator (NAM) that targets metabotropic glutamate receptors 2 and 3 (mGlu2, mGlu3). RO4988546 can reduce the binding of [3h]-LY354740 at the positive binding site, while affecting the receptor's G protein coupling and intracellular signaling. RO4988546 can be used in the development of antidepressants and cognitive enhancers[1]. | [References]
[1] Lundstr?m, et al. Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. British journal of pharmacology 164.2b (2011): 521-537. DOI:10.1111/j.1476-5381.2011.01409.x |
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