| Identification | Back Directory | [Name]
NW-1172 | [CAS]
911290-20-5 | [Synonyms]
NW-1172
NW-1772 free base
2H-1-Benzopyran-2-one, 7-[(3-chlorophenyl)methoxy]-4-[(methylamino)methyl]- | [Molecular Formula]
C18H16ClNO3 | [MDL Number]
MFCD16627987 | [MOL File]
911290-20-5.mol | [Molecular Weight]
329.78 |
| Hazard Information | Back Directory | [Uses]
NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor. | [References]
[1] Pisani L, et al. Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl) oxy]-4-[(methylamino) methyl]-2 H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor[J]. Journal of medicinal chemistry, 2009, 52(21): 6685-6706. DOI:10.1021/jm9010127 |
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Key Organics Ltd.
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