| Identification | Back Directory | [Name]
(2-{4-[3-Fluoro-2-(2-methoxy-phenyl)-1H-indol-5-yl]-piperidin-1-yl}-ethyl)-methyl-amine | [CAS]
912970-79-7 | [Synonyms]
PRMT4-IN-1
1-Piperidineethanamine, 4-[3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl]-N-methyl-
2-(4-(3-Fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)piperidin-1-yl)-N-methylethan-1-amine
(2-{4-[3-Fluoro-2-(2-methoxy-phenyl)-1H-indol-5-yl]-piperidin-1-yl}-ethyl)-methyl-amine | [Molecular Formula]
C23H28FN3O | [MOL File]
912970-79-7.mol | [Molecular Weight]
381.49 |
| Hazard Information | Back Directory | [Uses]
PRMT6-IN-2 (compound 2) is a dual inhibitor of protein arginine methyltransferase PRMT6 and CARM1 with an IC50 of 30 nM. PRMT6 is abnormally expressed in many cancer cells, and PRMT6-IN-2-based derivatives have potential anticancer activity. | [References]
[1] Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor |
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