| Identification | Back Directory | [Name]
FostaMatinib DisodiuM Hexahydrate | [CAS]
914295-16-2 | [Synonyms]
914295-16-2
Fostamatinib Na
R788 (disodiuM hexahydrate)
FostaMatinib DisodiuM Hexahydrate
Fostamatinib disodium salt hexahydrate
R788 Disodium Hexahydrate (Fostamatinib Disodium Hexahydrate)
Fostamatinib Disodium Hexahydrate
DISCONTINUED. Please see R070115.
6-[[5-Fluoro-2-[(3,4,5-triMethoxyphenyl)aMino]-4-pyriMidinyl]aMino]-2,2-diMethyl-4-[(phosphonooxy)Methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one SodiuM Salt Hydrate
6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one disodium salt hexahydrate
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, disodium salt, hexahydrate | [Molecular Formula]
C23H24FN6Na2O9P | [MOL File]
914295-16-2.mol | [Molecular Weight]
624.423 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to gray | [InChIKey]
HSYBQXDGYCYSGA-UHFFFAOYSA-L | [SMILES]
C1(C)(C)Oc2ccc(Nc3c(F)cnc(Nc4cc(OC)c(OC)c(OC)c4)n3)nc2N(COP([O-])([O-])=O)C1=O.[Na+].[Na+] | [CAS DataBase Reference]
914295-16-2 |
| Hazard Information | Back Directory | [Uses]
A spleen tyrosine kinase inhibitor prodrug for the treatment of inflammatory diseases.
| [in vivo]
Fostamatinib (R788) is highly bioavailable, and rapidly absorbed in Louvain rats. R406 following a single oral dose of R788 10 mg/kg or 20 mg/kg: AUC0-16 hrs= 10618 ng*h/mL and 30650 ng*h/mL respectively; Cmax=2600 ng/mL and 6500 ng/mL respectively (observed at 1 hour); t1/2=4.2 hours. The prodrug was not detected in plasma suggesting R788 is completely converted to R406[1]. | [storage]
Store at -20°C |
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