| Identification | Back Directory | [Name]
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone | [CAS]
915095-86-2 | [Synonyms]
Englenet Impurity 16
Empagliflozin Impurity 48
(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)- | [EINECS(EC#)]
619-596-4 | [Molecular Formula]
C13H7ClFIO | [MDL Number]
MFCD22665920 | [MOL File]
915095-86-2.mol | [Molecular Weight]
360.55 |
| Chemical Properties | Back Directory | [Melting point ]
64-70oC | [Boiling point ]
415℃ | [density ]
1.752 | [Fp ]
205℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate | [form ]
Solid | [color ]
Off-White | [InChI]
InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H | [InChIKey]
KNYGUQLVFSPVRI-UHFFFAOYSA-N | [SMILES]
C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O |
| Hazard Information | Back Directory | [Uses]
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2. | [Synthesis]
5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained. | [References]
[1] Patent: CN105399735, 2016, A. Location in patent: Paragraph 0037; 0038; 0039
[2] Patent: US2006/258749, 2006, A1. Location in patent: Page/Page column 21
[3] Organic Letters, 2014, vol. 16, # 16, p. 4090 - 4093
[4] Patent: WO2015/101916, 2015, A1. Location in patent: Page/Page column 18; 19
[5] Patent: CN106928040, 2017, A. Location in patent: Paragraph 0038-0039 |
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Energy Chemical
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China Langchem Inc.
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T&W GROUP
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