| Identification | Back Directory | [Name]
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- | [CAS]
915759-45-4 | [Synonyms]
CS-2786
WAY 316606
WAY-316606
way-316606 /way 316606
WAY-316606;WAY 316606;WAY316606
5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide
5-(Phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C18H19F3N2O4S2 | [MDL Number]
MFCD18206894 | [MOL File]
915759-45-4.mol | [Molecular Weight]
448.48 |
| Chemical Properties | Back Directory | [Boiling point ]
601.1±65.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMSO: 3 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
Powder | [pka]
8.76±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2 | [InChIKey]
ITBGJNVZJBVPLJ-UHFFFAOYSA-N | [SMILES]
C1(S(NC2CCNCC2)(=O)=O)=CC(S(C2=CC=CC=C2)(=O)=O)=CC=C1C(F)(F)F |
| Hazard Information | Back Directory | [Description]
WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM).1 It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.2 | [Uses]
WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM[1]. | [Definition]
ChEBI: WAY-316606 is a sulfonamide resulting from the formal condensation of the sulfonic acid group of 5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonic acid with the primary amino group of piperidin-4-amine. An inhibitor of secreted Frizzled-Related Protein-1 (sFRP-1). It has a role as a secreted frizzled-related protein 1 inhibitor. It is a sulfone, a sulfonamide, a member of (trifluoromethyl)benzenes, a member of piperidines and a secondary amino compound. | [in vivo]
WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC50 of about 1 nM. WAY-316606 exhibits moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t1/2>60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration[2]. | [References]
[1] Moore, WJ, et al. Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamides. Journal of Medicinal Chemistry (2009), 52(1), 105-116. DOI:10.1021/jm801144h
[2] Bodine PV, et al. A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation. Bone. 2009 Jun;44(6):1063-8. DOI:10.1016/j.bone.2009.02.013 |
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SPIRO PHARMA
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www.spiropharma.com.cn |
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Twochem Co.Ltd.
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021-58111628 15800915896 |
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cn.twochem.com |
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Henan Alfachem Co.,Ltd.
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0371-55051623 18137891487 |
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https://www.chemicalbook.com/supplier/14555231/ |
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