| Identification | Back Directory | [Name]
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate | [CAS]
915967-82-7 | [Synonyms]
Piperaquine tetraphosphate tetrahydrate
1,3-Bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane Tetraphosphate
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate hydrate
1,3-Bis[4-(7-chloro-4-quinolinyl)-1-piperazinyl]propane tetraphosphate tetrahydrate | [Molecular Formula]
C29H32Cl2N6.4(H3PO4).4(H2O) | [MDL Number]
MFCD11870901 | [MOL File]
915967-82-7.mol | [Molecular Weight]
651.521 |
| Chemical Properties | Back Directory | [Melting point ]
252 °C(dec.) | [storage temp. ]
room temp | [solubility ]
H2O: ≥10mg/mL | [form ]
Powder | [color ]
white to off-white | [Water Solubility ]
H2O: ≥10mg/mL | [Sensitive ]
Hygroscopic | [InChIKey]
AMCQDGFOKTXHSY-UHFFFAOYSA-N | [SMILES]
O.O.O.O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.Clc1ccc2c(ccnc2c1)N3CCN(CCCN4CCN(CC4)c5ccnc6cc(Cl)ccc56)CC3 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26 | [WGK Germany ]
3 | [HS Code ]
2933.59.8000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Piperaquine tetraphosphate tetrahydrate has been used to study its effect on the tert-butylhydroperoxide (t-BHP)-induced alterations of cell morphology and viability | [Biochem/physiol Actions]
Piperaquine tetraphosphate tetrahydrate is an antimalarial agent highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax. | [in vivo]
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1]. | Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] | | Dosage: | 0, 10, 30, 90 mg/kg | | Administration: | A single i.p. administration | | Result: | The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
|
| Animal Model: | Male Swiss mice (6 weeks old)[1] | | Dosage: | 90 mg/kg (Pharmacokinetic Analysis) | | Administration: | A single i.p. administration | | Result: | t1/2=17.8 d; AUC=33.5 mg?h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
| [IC 50]
Plasmodium |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|