| Identification | Back Directory | [Name]
Naldemedine | [CAS]
916072-89-4 | [Synonyms]
Morphinan-7-carboxamide, 17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-3,6,14-trihydroxy-N-[1-methyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethyl]-, (5α)- | [Molecular Formula]
C32H34N4O6 | [MDL Number]
MFCD30532638 | [MOL File]
916072-89-4.mol | [Molecular Weight]
570.64 |
| Hazard Information | Back Directory | [Uses]
Isotope labelled Naldemedine is a peripherally selective mu opioid receptor antagonist used in the treatment in pain. | [in vivo]
Naldemedine (oral gavage; 0.03-10 mg/kg; once) represses the opioid-induced inhibition of small intestinal transit in rats by subcutaneous morphine and oxycodone[2]. | Animal Model: | 6-week-old Wistar and SD male rats[2] | | Dosage: | 0.03-10 mg/kg | | Administration: | Oral gavage; 0.03-10 mg/kg; once | | Result: | Repressed the subcutaneous morphine-induced inhibition of small intestinal transit in rats with an ED50 of 0.03 mg/kg, and the oxycodone-induced inhibition model with an ED50 of 0.02 mg/kg. |
| [storage]
Store at -20°C |
|
| Company Name: |
TOSUN PHARM
|
| Tel: |
020-61855200 13326451905 |
| Website: |
www.toref.cn/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|