| Identification | Back Directory | [Name]
Atomoxetine D7Q: What is
Atomoxetine D7 Q: What is the CAS Number of
Atomoxetine D7 Q: What is the storage condition of
Atomoxetine D7 Q: What are the applications of
Atomoxetine D7 | [CAS]
919104-07-7 | [Synonyms]
Atomoxetine D7Q: What is
Atomoxetine D7 Q: What is the CAS Number of
Atomoxetine D7 Q: What is the storage condition of
Atomoxetine D7 Q: What are the applications of
Atomoxetine D7 |
| Hazard Information | Back Directory | [Uses]
Atomoxetine-d7 (Tomoxetine-d7) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with Ki values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DAEX and NEEX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na+ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research[1][2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Turner M, et, al. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2013 Apr 15;243:28-37. DOI:10.1016/j.bbr.2012.12.025
[3] F?hr KJ, et, al. Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner. Front Pharmacol. 2021 Feb 25;12:622489. DOI:10.3389/fphar.2021.622489
[4] Bymaster FP, et, al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. DOI:10.1016/S0893-133X(02)00346-9 |
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