| Hazard Information | Back Directory | [Uses]
Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1]. | [IC 50]
BChE: 1.4 μM (IC50, [1]) | [References]
[1] Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15(6):1135-1156. DOI:10.1021/acschemneuro.3c00737 |
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