920845-86-9

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920845-86-9 Structure

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[density ] 1.313±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 10.32±0.50(predicted)

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[Uses] Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1].
[IC 50] BChE: 1.4 μM (IC₅₀, ^[1])
[References] [1] Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15(6):1135-1156. DOI:10.1021/acschemneuro.3c00737

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