| Identification | Back Directory | [Name]
obafluorin | [CAS]
92121-68-1 | [Synonyms]
obafluorin
N-[(3S)-2-Oxo-4β-(4-nitrobenzyl)oxetan-3β-yl]-2,3-dihydroxybenzamide
Benzamide, 2,3-dihydroxy-N-[(2R,3S)-2-[(4-nitrophenyl)methyl]-4-oxo-3-oxetanyl]- | [Molecular Formula]
C17H14N2O7 | [MOL File]
92121-68-1.mol | [Molecular Weight]
358.3 |
| Hazard Information | Back Directory | [Description]
Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens. It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). | [Uses]
Obafluorin is a β-Lactone Antibiotic, that can be produced by Pseudomonas fluorescens ATCC 39502. Obafluorin exhibits antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Obafluorin fully inhibits E. coli threonyl-tRNA synthetase[1]. | [storage]
Store at -20°C | [References]
[1] Scott TA, et al. Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic. ACS Chem Biol. 2019 Dec 20;14(12):2663-2671. DOI:10.1021/acschembio.9b00590 |
|
|