921609-34-9

921623-42-9

921609-34-9

General procedure for the synthesis of (S)-2-amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid hydrochloride from the compound (CAS: 921623-42-9): methyl (2S)-2-(acetylamino)-3-[4-(trifluoromethoxy)phenyl]propanoate (29.9 mg, 0.098 mmol) prepared in Reference Example 3 was mixed with 6 N hydrochloric acid ( 330 μL) were mixed and the reaction was stirred at 100 °C for 4 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure. The resulting residue was azeotroped with toluene, washed with ether and dried under reduced pressure to give 26 mg (S)-2-amino-3-(4-(trifluoromethoxy)phenyl)propionic acid hydrochloride (white powder, yield: 93%).