ChemicalBook--->CAS DataBase List--->922139-31-9

922139-31-9

922139-31-9 Structure

922139-31-9 Structure
IdentificationBack Directory
[CAS]

922139-31-9
[Molecular Formula]

C16H12ClNaO4S
[Molecular Weight]

360.78
Hazard InformationBack Directory
[Uses]

Recilisib sodium (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells[1].
[in vivo]

Recilisib sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure[1].

[References]

[1] Kang AD, et al. ON01210.Na (Ex-RAD) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. DOI:10.1371/journal.pone.0058355
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