| Identification | Back Directory | [Name]
6-cyclopropyl-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | [CAS]
923894-97-7 | [Synonyms]
GSKA
GSK-A
GSK A
6-cyclopropyl-N-((2-hydroxy-4,6-dimethylpyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
6-cyclopropyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide | [Molecular Formula]
C21H25N5O2 | [MDL Number]
MFCD08270640 | [MOL File]
923894-97-7.mol | [Molecular Weight]
379.46 |
| Hazard Information | Back Directory | [Description]
GSK-A is an inhibitor of the Histone Lysine Methyltransferase EZH2. | [Uses]
EZH2-IN-21 is a potent inhibitor of the histone lysine methyltransferase enhancer of zeste homologue 2 (EZH2) with anticancer activity. EZH2-IN-21 is competitive with the cofactor SAM and noncompetitive with peptide or nucleosome substrates[1]. | [References]
[1] Verma SK, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. DOI:10.1021/ml3003346 |
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