| Identification | Back Directory | [Name]
methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate | [CAS]
92406-53-6 | [Synonyms]
Methyl 5-Amino-1-methylpyrazole-3-carboxylate
methyl 5-amino-1-methyl-1H-pyrazole-3-carboxylate
Methyl 5-amino-1-methylpyrazole-3-carboxylic acid
5-Amino-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester
1H-Pyrazole-3-carboxylic acid, 5-amino-1-methyl-, methyl ester | [Molecular Formula]
C6H9N3O2 | [MDL Number]
MFCD10697500 | [MOL File]
92406-53-6.mol | [Molecular Weight]
155.15 |
| Chemical Properties | Back Directory | [Melting point ]
101-102 °C | [Boiling point ]
326.2±22.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
1.74±0.10(Predicted) | [Appearance]
Off-white to pink Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 5-amino-1-methylpyrazole-3-carboxylate from methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate: Methyl 1-methyl-5-nitro-1H-pyrazole-3-carboxylate (136 mg, 0.74 mmol) obtained in Preparation Example 21 was dissolved in 2 mL of methanol, and 14 mg of 10% palladium/charcoal catalyst was slowly added dropwise. The reaction was stirred at room temperature for 1 hour under hydrogen pressure of 50 atm. Upon completion of the reaction, the reaction mixture was filtered through a pad of diatomaceous earth to remove the catalyst and the filtrate was concentrated under reduced pressure to afford 94 mg (82% yield) of the target compound, methyl 5-amino-1-methylpyrazole-3-carboxylate. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.12 (s, 1H, pyrazole ring H), 3.99 (s, 3H, OCH3), 3.84 (s, 3H, N-CH3), 3.72 (brs, 2H, NH2). | [References]
[1] Patent: US2010/63106, 2010, A1. Location in patent: Page/Page column 13
[2] Patent: WO2008/51047, 2008, A1. Location in patent: Page/Page column 34 |
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