| Identification | Back Directory | [Name]
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
926319-75-7 | [Synonyms]
CK59
CK-59
CK 59
(6-[2-(2-HYDROXY-ETHYLAMINO)-9-ISOPROPYL-9H-PURIN-6-YLAMINO]-HEXYL)-CARBAMIC ACID TERT-BUTYL ESTER | [Molecular Formula]
C21H37N7O3 | [MDL Number]
MFCD11856052 | [MOL File]
926319-75-7.mol | [Molecular Weight]
435.56 |
| Hazard Information | Back Directory | [Description]
CK59 is calcium-calmodulin-dependent kinase II (CaMKII) inhibitor. CK59 inhibits multiple voltage-gated calcium channels, including the L-type channel during depolarization in a dose-dependent manner. The IC50 for CK59 was approximately 50 μM, which is only fivefold larger than the reported IC50 values for CaMKII inhibition. The inhibition due to CK59 was reversible; washout of the drug brought calcium levels back to control values upon depolarization. | [Uses]
Protein kinase inhibitor 8 (Compound CK59) is a calmodulin-dependent protein kinase II (CaMKII) inhibitor. By inhibiting the activity of CaMKII, Protein kinase inhibitor 8 can attenuate the cytotoxicity induced by perfluorooctane sulfonic acid (PFOS) and alleviate the downregulation of GLT-1 expression caused by PFOS, thereby reducing neuronal damage. Protein kinase inhibitor 8 may be useful in research related to neurodegenerative diseases[1][2]. | [IC 50]
CaMK II | [References]
[1] Yang J, et al. PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model. Neurochem Res. 2024 May;49(5):1226-1238. DOI:10.1007/s11064-024-04109-9
[2] Scheiter M, et al. Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Front Immunol. 2013 Mar 18;4:66. DOI:10.3389/fimmu.2013.00066 |
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