| Identification | Back Directory | [Name]
15(S)-HEDE | [CAS]
92693-04-4 | [Synonyms]
15(S)-HEDE
ZTRWPEHMGCHTIT-XMSPSUPSSA-N
15S-HYDROXY-11Z,13E-EICOSADIENOIC ACID
15(S)-HYDROXYEICOSA-11Z,13E-DIENOIC ACID | [Molecular Formula]
C20H36O3 | [MDL Number]
MFCD00211011 | [MOL File]
92693-04-4.mol | [Molecular Weight]
324.5 |
| Chemical Properties | Back Directory | [Boiling point ]
475.0±18.0 °C(Predicted) | [density ]
0.958±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | [pka]
4.78±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM.1 | [Uses]
15(S)-HEDE (Compound 8) is an analogue of 15-HEDE (HY-121987A) that inhibits 5-lipoxygenase with an IC50 value of 26 μM. 15(S)-HEDE is promising for research of inflammatory disease[1]. | [storage]
Store at -20°C | [References]
1. Haviv, F., Ratajczyk, J.D., DeNet, R.W., et al. Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogues J. Med. Chem. 30(2),254-263(1987). |
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
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