927887-18-1

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927887-18-1 Structure

Identification	Back Directory
[Name] Ro 4 hydrochloride
[CAS] 927887-18-1
[Synonyms] Ro 4 hydrochloride AF-353 hydrochloride 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride
[Molecular Formula] C14H18ClIN4O2
[MDL Number] MFCD18917216
[MOL File] 927887-18-1.mol
[Molecular Weight] 436.676

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMSO: >10mg/mL
[form ] A crystalline solid
[color ] off-white to light brown

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H335-H319-H315
[Precautionary statements ] P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
[Hazard Codes ] Xn
[Risk Statements ] 22-36/37/38
[Safety Statements ] 26

Hazard Information	Back Directory
[Uses] AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
[storage] -20°C
[References] [1] Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. DOI:10.1111/j.1476-5381.2010.00796.x [2] Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. DOI:10.1111/j.1464-410X.2012.11189.x

927887-18-1 suppliers list

Company Name:	Changzhou Chenhong Biotechnology Co., Ltd.
Tel:	+86-0519-85788828 +86-13775037613
Website:	http://www.chemrenblock.com/

Company Name:	JinOu Biomedical (Nanjing) Co., Ltd.
Tel:	13000000000
Website:	www.chemicalbook.com/ShowSupplierProductsList1596079/0_EN.htm

Company Name:	Shanghai Yifei Biotechnology Co. , Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

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