| Identification | Back Directory | [Name]
5-BroMoquinoline-8-carboxylic acid | [CAS]
928839-62-7 | [Synonyms]
5-BroMoquinoline-8-carboxylic acid
8-Quinolinecarboxylic acid, 5-bromo- | [Molecular Formula]
C10H6BrNO2 | [MOL File]
928839-62-7.mol | [Molecular Weight]
252.06 |
| Chemical Properties | Back Directory | [Boiling point ]
425.9±30.0 °C(Predicted) | [density ]
1.732±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
-2.39±0.10(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 2: 5-bromo-8-methylquinoline (from Step 1) was dissolved in H2SO4-H2O (3:2) to prepare a 0.1 M solution. CrO3 (10 equiv.) was added to this solution and the reaction was carried out at 90 °C for 2 hours. After completion of the reaction, the mixture was poured into ice water and the precipitate was collected by filtration to afford 5-bromoquinoline-8-carboxylic acid in 62% yield as an orange solid. Mass spectrum (ES+) m/z 252,254 (M+H)+. | [References]
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 8, p. 2836 - 2848
[2] Patent: WO2007/28789, 2007, A1. Location in patent: Page/Page column 34
[3] Patent: WO2013/96194, 2013, A1
[4] Patent: WO2015/84842, 2015, A1. Location in patent: Paragraph 0089
[5] Patent: WO2009/141386, 2009, A1. Location in patent: Page/Page column 162; 163 |
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| Company Name: |
Tetranov Biopharm
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| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
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