| Identification | Back Directory | [Name]
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- | [CAS]
928892-60-8 | [Synonyms]
CB2R/FAAH modulator-1
CB2R/FAAHu00A0modulator-1
Benzamide, 2-(phenylmethoxy)-N-tricyclo[3.3.1.13,7]dec-1-yl- | [Molecular Formula]
C24H27NO2 | [MOL File]
928892-60-8.mol | [Molecular Weight]
361.48 |
| Hazard Information | Back Directory | [Uses]
CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1]. | [IC 50]
CB2R: 14.8 nM (Ki); CB2R: 123.6 nM (EC50); CB1R: 241.3 nM (Ki); CB1R: 489 nM (EC50) | [References]
[1] Francesca Intranuov, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250. DOI:10.1021/acs.jmedchem.2c01084 |
|
|