| Identification | Back Directory | [Name]
S-110 | [CAS]
929904-85-8 | [Synonyms]
S-110
SGI-100
S-110 sodium
Guadecitabine (SGI-110)
XLHBNJPXFOZFNJ-UHFFFAOYSA-M
SGI-110 SODIUM;S-110 SODIUM
2'-Deoxy-5-azacytidylyl-(3'→5')-2'-deoxy-guanosine SodiuM Salt
[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl [(2R,3S,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] phosphate | [Molecular Formula]
C18H25N9NaO10P | [MDL Number]
MFCD28138338 | [MOL File]
929904-85-8.mol | [Molecular Weight]
581.41 |
| Hazard Information | Back Directory | [Uses]
2'-Deoxy-5-azacytidylyl-(3'→5')-2'-deoxy-guanosine is an DNA methylation inhibitor in vivo and was shown to effectively tolerated in tumor-free mouse and was found to be similarly effective in reducing tumor growth. | [in vivo]
Guadecitabine sodium (SGI-110 sodium) at 10mg/kg is an effective dose at reducing DNA methylation and retarding tumor growth, and caused roughly the same level of toxicity as 5-Aza-CdR. Guadecitabine sodium is effective in vivo at reactivating the expression of the p16 gene, which is heavily methylated in the parent EJ6 cells. Guadecitabine sodium is effective in reducing the level of DNA methylation in vivo at the p16 promoter region. Guadecitabine sodium is better tolerated than 5-Aza-CdR in vivo, suggesting that it can be an attractive alternative for potential clinical use[2]. | [IC 50]
DNMT1 |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|