| Identification | Back Directory | [Name]
L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- | [CAS]
929905-12-4 | [Synonyms]
PAMP-12
FRKKWNKWALSR
L-Arginine, L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl- | [Molecular Formula]
C77H118N24O15 | [MOL File]
929905-12-4.mol | [Molecular Weight]
1619.91 |
| Hazard Information | Back Directory | [Uses]
PAMP-12 (unmodified) is a potent MRGPRX2 (MrgX2) agonist (EC50=20-50 nM). PAMP-12 (unmodified) is an endogenous peptide that elicit hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells[1]. | [References]
[1] Kamohara M, et al. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem Biophys Res Commun. 2005;330(4):1146-1152. DOI:10.1016/j.bbrc.2005.03.088
[2] Chen E, et al. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target. Gastroenterology. 2021;160(5):1709-1724. DOI:10.1053/j.gastro.2020.12.076 |
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Biorbyt Ltd.
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