| Identification | Back Directory | [Name]
DG 051 (HCl salt) | [CAS]
929915-58-2 | [Synonyms]
DG051
DG051
(DG-051
DG 051 (HCl salt)
(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride
4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride | [Molecular Formula]
C21H25Cl2NO4 | [MDL Number]
MFCD18251532 | [MOL File]
929915-58-2.mol | [Molecular Weight]
426.334 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml | [form ]
Solid | [color ]
White to light yellow | [InChI]
InChI=1/C21H24ClNO4.ClH/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25;/h5-12,17H,1-4,13-15H2,(H,24,25);1H/t17-;/s3 | [InChIKey]
UCPVOTSNNAVKNE-VOPAOICTNA-N | [SMILES]
C(O)(=O)CCCN1CCC[C@H]1COC1=CC=C(OC2=CC=C(Cl)C=C2)C=C1.Cl |&1:10,r| |
| Hazard Information | Back Directory | [Description]
DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG. | [Uses]
(2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers. | [References]
[1] VINCENT SANDANAYAKA. Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis[J]. Journal of Medicinal Chemistry, 2009, 53 2: 573-585. DOI: 10.1021/jm900838g
[2] CAROLINE M LOW. The development of novel LTA4H modulators to selectively target LTB4 generation.[J]. Scientific Reports, 2017: 44449. DOI: 10.1038/srep44449 |
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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