| Identification | Back Directory | [Name]
1H-Pyrrolo[3,4-d]pyrimidine-2,5-dione, 3,4,6,7-tetrahydro-6-(2-hydroxypropyl)-4-(4-methylphenyl)- | [CAS]
930017-01-9 | [Synonyms]
1H-Pyrrolo[3,4-d]pyrimidine-2,5-dione, 3,4,6,7-tetrahydro-6-(2-hydroxypropyl)-4-(4-methylphenyl)- | [Molecular Formula]
C16H19N3O3 | [MOL File]
930017-01-9.mol | [Molecular Weight]
301.34 |
| Hazard Information | Back Directory | [Uses]
E28362 is a novel small molecule PCSK9 inhibitor. E28362 blocks the interaction between PCSK9 and LDLR, thereby preventing the degradation of LDLR and maintaining cholesterol homeostasia. E28362 is a promising lead compound for the study of hyperlipidemia and atherosclerosis[1]. | [References]
[1] Wang W, et al. A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis[J]. Acta Pharmacologica Sinica, 2024: 1-15. DOI:10.1038/s41401-024-01305-9 |
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