| Identification | Back Directory | [Name]
N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine | [CAS]
930039-92-2 | [Synonyms]
BRD4 Inhibitor-27
BRD4u00A0Inhibitor-27
N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
1,2,4-Triazolo[4,3-b]pyridazin-6-amine, N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)- | [Molecular Formula]
C16H13F3N6 | [MOL File]
930039-92-2.mol | [Molecular Weight]
346.31 |
| Hazard Information | Back Directory | [Uses]
BRD4 Inhibitor-27 (compound 6) is a BRD4 inhibitor with IC50 of 9.6 and 11.3 μM for BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-27 has the potential to study cancer[1]. | [IC 50]
BD1: 9.6 μM (IC50); BD2: 11.3 μM (IC50) | [References]
[1] Kim JH, et al. Crystal structure of [1,2,4] triazolo[4,3- b ]pyridazine derivatives as BRD4 bromodomain inhibitors and structure–activity relationship study . Sci Rep 13, 10805 (2023). |
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PHARMEKS Ltd.
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www.pharmeks.com |
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OTAVA chemicals
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www.otavachemicals.com |
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