| Identification | Back Directory | [Name]
5-AMINO-2H-ISOQUINOLIN-1-ONE | [CAS]
93117-08-9 | [Synonyms]
5-AIQ
5-aMinoisoquinolin-1-ol
5-Aminoisoquinolin-1(2H)
5-AMino-2H-isoquinolin-1-ol
5-amino-2H-isoquinoin-1-one
5-AMINO-2H-ISOQUINOLIN-1-ONE
5-Amino-1(2H)-isoquinolinone
5-aMinoisoquinolin-1(2H)-one
1(2H)-Isoquinolinone, 5-aMino-
1(2H)-Isoquinolinone,5-amino-(9CI)
5-aMino-1,2-dihydroisoquinolin-1-one
5-AMINO-2H-ISOQUINOLIN-1-ONE ISO 9001：2015 REACH
5-aMinoisoquinolin-1-ol/5-aMinoisoquinolin-1(2H)-one | [Molecular Formula]
C9H8N2O | [MDL Number]
MFCD06198896 | [MOL File]
93117-08-9.mol | [Molecular Weight]
160.17 |
| Chemical Properties | Back Directory | [Melting point ]
249-250°C | [density ]
1.287 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Light Beige to Light Brown |
| Hazard Information | Back Directory | [Uses]
5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors. | [Definition]
ChEBI: 5-amino-2H-isoquinolin-1-one is a member of isoquinolines. | [in vivo]
5-AIQ (150 and 250 mg/kg; p.o.; once) possess no significantly genotoxic in vivo system by micronucleus test[1].
5-AIQ (3 mg/kg; p.o.; 5 min prior to onset of liver ischemia) reduces the tissue injury associated with ischemia-reperfusion of the liver[2]. | Animal Model: | Male mice[1] | | Dosage: | 150 and 250 mg/kg | | Administration: | Oral administration; 150 and 250 mg/kg; once | | Result: | Showed no increase of micronucleated polychromatic erythrocytes (MNPCE) in both 24 h and 48 h after both 125 and 250 mg/kg duration exposure as compared to the corresponding control.
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| Animal Model: | Anesthetised male Wistar rats with liver ischemia (for 30 minutes) and reperfusion (for 2 hours) [2] | | Dosage: | 3 mg/kg | | Administration: | Intravenous injection; 3 mg/kg; 5 min prior to onset of liver ischemia | | Result: | Reduced PARP activation and showed less staining for ICAM-1.
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| [storage]
4°C, protect from light |
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