| Identification | Back Directory | [Name]
Endixaprine | [CAS]
93181-85-2 | [Synonyms]
SR 41378
Endixaprine
1-[6-(2,4-Dichlorophenyl)-3-pyridazinyl]-4-piperidinol
4-Piperidinol, 1-[6-(2,4-dichlorophenyl)-3-pyridazinyl]- | [Molecular Formula]
C15H15Cl2N3O | [MDL Number]
MFCD00865325 | [MOL File]
93181-85-2.mol | [Molecular Weight]
324.21 |
| Chemical Properties | Back Directory | [Melting point ]
151-153 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
545.3±50.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Predicted) | [pka]
14.56±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
SR 41378 is an orally active aminopyrazine derivative. SR 41378 has anticonvulsant, antianxiety and hypnotic activities[1][2]. | [in vivo]
SR 41378 (1.25-20 mg/kg, intraperitoneal injection) can significantly reduce the incidence and severity of seizures in rats[1].
| [References]
[1] Santucci V, et al. Quantitative electroencephalographic profile of 3-(4-hydroxy-1-piperidinyl)-6-(2,4-dichlorophenyl)-pyridazine (SR 41378) in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):186-9. DOI:10.1007/BF00506525 |
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