| Identification | Back Directory | [Name]
Acetic acid, [2-(phenylmethoxy)ethoxy]- | [CAS]
93206-09-8 | [Synonyms]
BnO-PEG1-CH2COOH
[2-(Benzyloxy)ethoxy]acetic acid
2-(2-(benzyloxy)ethoxy)acetic acid
Acetic acid, [2-(phenylmethoxy)ethoxy]- | [Molecular Formula]
C11H14O4 | [MDL Number]
MFCD16294180 | [MOL File]
93206-09-8.mol | [Molecular Weight]
210.226 |
| Chemical Properties | Back Directory | [Boiling point ]
372.2±22.0 °C(Predicted) | [density ]
1.173±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.40±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Benzyl-PEG2-CH2CO2H is a PEG linker with a benzyl protecting group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound. | [Uses]
BnO-PEG1-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. | [IC 50]
PEGs | [References]
[1] Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67. DOI:10.3762/bjoc.11.74 |
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