| Identification | Back Directory | [Name]
5-Iodo-2-pyrimidinone-2'-deoxyribose | [CAS]
93265-81-7 | [Synonyms]
IPdR
Ropidoxuridine
Idoxuridine Impurity 2
Idoxuridine Deoxy Impurity
5-Iodo-2-pyrimidinone-2'-deoxyribose
1-(2-deoxy-beta-ribofuranosyl)-5-iodo-2-pyrimidinone
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one | [Molecular Formula]
C9H11IN2O4 | [MDL Number]
MFCD13194773 | [MOL File]
93265-81-7.mol | [Molecular Weight]
338.1 |
| Chemical Properties | Back Directory | [Melting point ]
160-170 °C (decomp) | [Boiling point ]
478.6±55.0 °C(Predicted) | [density ]
2.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.03±0.60(Predicted) | [color ]
Light yellow to green yellow | [SMILES]
O=C1N(C=C(C=N1)I)[C@@H]2O[C@@H]([C@H](C2)O)CO |
| Hazard Information | Back Directory | [Uses]
Ropidoxuridine is a pyrimidinone nucleoside prodrug of 5-iododeoxyuridine (IUdR) (I205750), an antitumor nucleoside enantiomer thymidine kinase used as potential antiviral agents. | [in vivo]
In an orthotopic tumor model, Ropidoxuridine (750 mg/kg/day) and Alisertib (30 mg/kg/day) demonstrate strong synergy effects[1]. |
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