| Identification | Back Directory | [Name]
EPIROSMANOL | [CAS]
93380-12-2 | [Synonyms]
EPIROSMANOL
6β,20-Epoxy-7β,11,12-trihydroxyabieta-8,11,13-triene-20-one
(4aR)-1,3,4,9,10,10aα-Hexahydro-5,6,9β-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-2H-10β,4aβ-(epoxymethano)phenanthren-12-one
2H-10,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9R,10S,10aS)-
Epirosmanol,inhibit,melanoma cells,scavenging activity,melanin,Inhibitor,antioxidant,diterpene lactone,S. officinalis,DPPH radical,anti-tumor | [Molecular Formula]
C20H26O5 | [MDL Number]
MFCD31557425 | [MOL File]
93380-12-2.mol | [Molecular Weight]
346.42 |
| Chemical Properties | Back Directory | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C20H26O5/c1-9(2)10-8-11-12(15(23)13(10)21)20-7-5-6-19(3,4)17(20)16(14(11)22)25-18(20)24/h8-9,14,16-17,21-23H,5-7H2,1-4H3/t14-,16-,17+,20+/m1/s1 | [InChIKey]
LCAZOMIGFDQMNC-PYQAKABTSA-N | [SMILES]
C1(C)(C)[C@@]2([H])[C@]3(C(=O)O[C@]2([H])[C@H](O)C2=C3C(O)=C(O)C(C(C)C)=C2)CCC1 |
| Hazard Information | Back Directory | [Uses]
Epirosmanol is a nature diterpene lactone from S. officinalis. Epirosmanol shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. Epirosmanol also exhibits DPPH radical scavenging activity[1][2]. | [Definition]
ChEBI: Epirosmanol is a diterpene lactone. | [References]
[1] Sallam A, et al. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016 Sep 15. 23(10):1005-11. DOI:10.1016/j.phymed.2016.06.014
[2] Miura K, et al. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002 Mar 27;50(7):1845-51. DOI:10.1021/jf011314o |
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