| Identification | Back Directory | [Name]
CONANTOKIN G | [CAS]
93438-65-4 | [Synonyms]
CGX-1007
CONANTOKIN G
conotoxin GV
''SLEEPER PEPTIDE''
M.W. 2264.1 C88H138N26O44
Conotoxin GV, Sleeper Peptide
GE(GLA)(GLA)LQ(GLA)NQ(GLA)LIR(GLA)KSN-NH2
CONANTOKIN G (MARINE SNAIL, CONUS GEOGRAPHUS)
GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2
H-GLY-GLU-GLA-GLA-LEU-GLN-GLA-ASN-GLN-GLA-LEU-ILE-ARG-GLA-LYS-SER-ASN-NH2
GLY-GLU-GAMMA-CARBOXYGLU-GAMMA-CARBOXYGLU-LEU-GLN-GAMMA-CARBOXYGLU-ASN-GLN-GAMMA-CARBOXYGLU-LEU-ILE-ARG-GAMMA-CARBOXYGLU-LYS-SER-ASN-NH2
L-Aspartamide, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-leucyl-L-glutaminyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-glutaminyl-4-carboxy-L-α-glutamyl-L-leucyl-L-isoleucyl-L-arginyl-4-carboxy-L-α-glutamyl-L-lysyl-L-seryl- | [Molecular Formula]
C88H138N26O44 | [MDL Number]
MFCD00214606 | [MOL File]
93438-65-4.mol | [Molecular Weight]
2264.19 |
| Hazard Information | Back Directory | [Uses]
Non-competitive inhibitor of NMDA glutamatergic receptors acting at the polyamine site. Conantokin G (CGX-1007), a member of the conantokin family, is a selective NR2B subunit inhibitor of NMDA glutamatergic receptors with activity as a neuroprotective agent against NMDA-induced excitotoxicity. | [General Description]
The most selective and potent non-competitive antagonist among the members of the conantokin peptide family for NR2B-containing NMDAR channels (Ki = 0.8 μM with close to 100% inhibition of NR1/NR2B mediated current). Widely used for studies related to NMDAR neurotransmissions in both peripheral and center nervous systems. | [Biochem/physiol Actions]
Primary TargetNMDA receptors | [IC 50]
NMDA Receptor | [storage]
Store at -20°C |
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