| Identification | Back Directory | [Name]
MK-0952 | [CAS]
934995-87-6 | [Synonyms]
MK-0952
Cyclopropanecarboxylic acid, 2-[3'-[3-[(cyclopropylaMino)carbonyl]-4-oxo-1,8-naphthyridin-1(4H)-yl]-3-fluoro[1,1'-biphenyl]-4-yl]-, (1R,2R)- | [Molecular Formula]
C28H22FN3O4 | [MDL Number]
MFCD20489052 | [MOL File]
934995-87-6.mol | [Molecular Weight]
483.49 |
| Hazard Information | Back Directory | [Uses]
MK-0952 is a selective and orally active PDE4 inhibitor, with an IC50 of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study[1][2]. | [in vivo]
MK-0952 (10 mg/kg) induces malaise in the rat[1]. | [IC 50]
PDE4: 0.53 nM (IC50) | [References]
[1] Michel Gallant, et al. Discovery of MK-0952, a Selective PDE4 Inhibitor for the Treatment of Long-Term Memory Loss and Mild Cognitive Impairment. Epub 2010 Sep 21. DOI:10.1016/j.bmcl.2010.09.087
[2] Tingting Pan, et al. Dual Functional Cholinesterase and PDE4D Inhibitors for the Treatment of Alzheimer's Disease: Design, Synthesis and Evaluation of tacrine-pyrazolo[3,4-b]pyridine Hybrids. Behav Brain Res. 2016 Apr 15;303:26-33. DOI:10.1016/j.bmcl.2019.06.056 |
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