| Identification | Back Directory | [Name]
(2E,4E,6E)-7-[3-hydroxy-5-[(4E,6E)-3-methoxy-4-methyl-8-[2-[2,4,5-trih ydroxy-5-methyl-6-[(1E,3E)-penta-1,3-dienyl]oxan-2-yl]butanoylamino]oc ta-4,6-dien-2-yl]oxolan-2-yl]hepta-2,4,6-trienoic acid | [CAS]
93522-10-2 | [Synonyms]
L681
L-681
L 681
L 681217
(2E,4E,6E)-7-[3-hydroxy-5-[(4E,6E)-3-methoxy-4-methyl-8-[2-[2,4,5-trih ydroxy-5-methyl-6-[(1E,3E)-penta-1,3-dienyl]oxan-2-yl]butanoylamino]oc ta-4,6-dien-2-yl]oxolan-2-yl]hepta-2,4,6-trienoic acid
2,4,6-Heptatrienoic acid, 7-[tetrahydro-3-hydroxy-5-[2-methoxy-1,3-dimethyl-7-[[1-oxo-2-[tetrahydro-2,4,5-trihydroxy-5-methyl-6-(1,3-pentadien-1-yl)-2H-pyran-2-yl]butyl]amino]-3,5-heptadien-1-yl]-2-furanyl]- | [Molecular Formula]
C36H53NO10 | [MDL Number]
MFCD09752705 | [MOL File]
93522-10-2.mol | [Molecular Weight]
659.812 |
| Hazard Information | Back Directory | [Uses]
L 681,217 is a glycolipid-type antibiotic related to the efrotomycin class, isolated from a Streptomyces sp.. L 681,217 also shows broad spectrum antibiotic activity against Gram positive and Gram negative bacteria. L-681,217 inhibits bacterial protein synthesis at the elongation stage, its target being elongation factor Tu (EF-Tu). | [Uses]
L-681,217 is a glycolipid-type antibiotic related to the efrotomycin class, isolated from a Streptomyces sp.. L 681,217 shows broad spectrum antibiotic activity against Gram positive and Gram negative bacteria. L-681,217 inhibits bacterial protein synthesis at the elongation stage, its target being elongation factor Tu (EF-Tu). | [References]
[1] A J KEMPF. L-681,217, a new and novel member of the efrotomycin family of antibiotics.[J]. Journal of Antibiotics, 1986, 39 10: 1361-1367. DOI: 10.7164/antibiotics.39.1361
[2] C C HALL N H G J D Watkins. Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus.[J]. Antimicrobial Agents and Chemotherapy, 1989, 33 3: 322-325. DOI: 10.1128/aac.33.3.322 |
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