| Identification | Back Directory | [Name]
2-Amino-pyrimidine-5-boronic acid | [CAS]
936250-22-5 | [Synonyms]
>=95.0%
Minimum purity 95.0%
2-Amino-5-boronopyrimidine
2-AMinopyriMidine-5-boronic
2-Aminopyrimidine-5-boron...
2-Aminopyrimidine-5-boronicaci
2-aMino-4-pyMidine boronic acid
2-AMino-5-pyriMidineboronic acid
2-Aminopyrimidine-5-boronic acid
2-Aminopyrimidine-5-ylboronic acid
(2-amino-5-pyrimidinyl)boronic acid
Neu5Gc α(2-3)Gal β MP Glycoside >
Piperitone(mixtureof2enantiomers)>
2-aminopyrimidin-5-yl-5-boronic acid
2-Aminopyrimidine-5-boronic acid >=95.0%
Boronic acid, B-(2-amino-5-pyrimidinyl)-
Neu5Ac[1Me,4789Ac]α(2-6)Gal[24Bz,3Bn]-β-MP >
Galβ(1-3)GalNAcβ(1-3)Galα(1-4)Galβ(1-4)Glc-β-pNP >
2-Amino-pyrimidine-5-boronic acid ISO 9001：2015 REACH
1，3-Butanediol diacrylate， high purity，
1,3-Butylene glycol diacrylate
2-Aminopyrimidine-5-boronic Acid (contains varying amounts of Anhydride)
StandardMixtureofn-Paraffins(consistsofC17,C18,C19andC20)[StandardMaterialforGC]>
(2-aminopyrimidin-5-yl)boronic acid, 2-amino-pyrimidine-5-boronic acid, 2-aminopyrimidin-5-ylboronic acid, 2-aminopyrimidine-5-boronic acid, 2-amino-5-pyrimidylboronic acid, 2-amino-pyrimidin-5-yl-boronic acid, pyrimidin-2-ylamine-4-boronic acid | [Molecular Formula]
C4H6BN3O2 | [MDL Number]
MFCD07375147 | [MOL File]
936250-22-5.mol | [Molecular Weight]
138.92 |
| Chemical Properties | Back Directory | [Melting point ]
206-211℃ | [Boiling point ]
487.0±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
2.58±0.11(Predicted) | [color ]
Off-White | [Stability:]
Hygroscopic | [InChI]
1S/C4H6BN3O2/c6-4-7-1-3(2-8-4)5(9)10/h1-2,9-10H,(H2,6,7,8) | [InChIKey]
CGHYQZASLKERLV-UHFFFAOYSA-N | [SMILES]
Nc1ncc(cn1)B(O)O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36/37/39 | [WGK Germany ]
2 | [HS Code ]
2933599590 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
May contain varying amounts of anhydride | [Uses]
2-Aminopyrimidine-5-boronic acid is used as pharmaceutical intermediates. | [Synthesis]
Example 17 Synthesis of 2-aminopyrimidin-5-ylboronic acid III: [2-[(tert-butoxycarbonyl)amino]pyrimidin-5-yl]boronic acid (40.0 kg, 49 wt%, HPLC purity 82.0 mol) was dissolved in water (245 kg), and concentrated hydrochloric acid (39.6 L) was added slowly while keeping the temperature below 30°C. The reaction mixture was stirred for 12 hours and then cooled to 10°C. Subsequently, the pH of the mixture was adjusted to 6.5 with 50% aqueous sodium hydroxide solution while controlling the temperature below 15 °C and stirring was continued for 1 hour. After adding water (69.0 kg), the mixture was aged for 30 minutes. The resulting slurry was filtered and the filter cake was dried under vacuum at 50 °C to afford the target product 2-aminopyrimidin-5-ylboronic acid III (10.2 kg, 90% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 8.50 (s, 2H), 7.97 (s, 2H), 6.74 (s, 2H). | [References]
[1] Patent: US2014/100366, 2014, A1. Location in patent: Page/Page column |
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