| Chemical Properties | Back Directory | [Boiling point ]
1930.0±65.0 °C(predicted) | [density ]
1.50±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
4.00±0.10(predicted) | [Sequence]
cyclo(CH2CO-Trp-Phe-Glu-Gly-Tyr-Asp-Asn-Thr-Phe-Pro-Cys(NH2)-S-) |
| Hazard Information | Back Directory | [Uses]
G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2]. | [References]
[1] Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. DOI:10.3390/molecules24203739
[2] Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15. DOI:10.1007/s10549-011-1822-6 |
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