| Hazard Information | Back Directory | [Uses]
ODN 1018 (1018 ISS), an oligodeoxynucleotide, is a TLR-9 agonist. ODN 1018 is also a synthetic immunostimulatory sequence that can be used as vaccine adjuvant. Sequence: 5′-TGACTGTGAACGTTCGAGATGA-3′[1][2]. | [IC 50]
TLR9 | [References]
[1] Friedberg JW, et al. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 Aug;146(3):282-91. DOI:10.1111/j.1365-2141.2009.07773.x
[2] Eng NF, et al. The potential of 1018 ISS adjuvant in hepatitis B vaccines: HEPLISAV? review. Hum Vaccin Immunother. 2013 Aug;9(8):1661-72. DOI:10.4161/hv.24715 |
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