| Identification | Back Directory | [Name]
4-Piperidinone, 1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]- | [CAS]
939318-04-4 | [Synonyms]
4-Piperidinone, 1-ethyl-3,5-bis[(2,3,4-trimethoxyphenyl)methylene]- | [Molecular Formula]
C27H33NO7 | [MOL File]
939318-04-4.mol | [Molecular Weight]
483.55 |
| Chemical Properties | Back Directory | [Boiling point ]
647.0±55.0 °C(Predicted) | [density ]
1.176±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (warmed) | [form ]
powder | [pka]
5.90±0.20(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
L48H37 has been used as a myeloid differentiator protein 2 (MD2) antagonist/inhibitor:
- to investigate intracellular signaling of LPS in signal transduction pathways via endosomic toll-like receptor 4 (TLR4) in colonic epithelium
- to determine its anti-cancer effects in pancreatic ductal adenocarcinoma (PDAC)
- to study its effects on lipopolysaccharide (LPS) and palmitate CC chemokine ligand 2 (CCL2) responses in normal kidney proximal tubule cells
| [Biological Activity]
L48H37 can stimulate apoptosis and prevent proliferation in pancreatic cancer cellsespecially in the absence of histone-lysine N-methyltransferase 2D (KMT2D). It has an unsaturated monoketone structurewhich helps to enhance its stability and anti-cancer effects. L48H37 may possess an anti-neoplastic effect on human pancreatic ductal adenocarcinoma (PDAC) cells.''L48H37 is a potent and chemically stable anti-inflammatory curcumin analog th at inhibits LPS-induced inflammation through the myeloid differentiation 2 (MD-2) and toll-like receptor 4 (TLR4) complex. L48H37 is a potent MD2 inhibitor th at binds to the hydrophobic region of MD-2 and blocks the interaction between MD2 and LPS. L48H37 significantly improves survival and protected lung injury in LPS-induced septic mice. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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