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94096-42-1

94096-42-1 Structure

94096-42-1 Structure
IdentificationBack Directory
[Name]

LU-43706
[CAS]

94096-42-1
[Synonyms]

LU-43706
(S)-Nafenodone
Dexnafenodone HCl
Dexnafenodone Hydrochloride
[Molecular Formula]

C20H24ClNO
[MOL File]

94096-42-1.mol
[Molecular Weight]

329.87
Hazard InformationBack Directory
[Description]

Dexnafenodone Hydrochloride, also known as LU-43706, is a dual of adrenergic receptor antagonist and serotonin uptake inhibitor potentially for the treatment of major depressive disorder.
[Uses]

Dexnafenodone hydrochloride ((S)-Nafenodone) as an antidepressant compound, is a potent and selective inhibitor of the synaptosomal uptake of noradrenaline, but has a less potent effect on serotonin uptake and a negligible effect on dopamine uptake.
[References]

[1] Pérez-Vizcaino F, Carrón R, Delpón E, Tamargo J. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. Eur J Pharmacol. 1991;199(1):43-50. DOI:10.1016/0014-2999(91)90635-4
[2] Pérez-Vizcaíno F, Carrón R, Delpón E, Duarte J, Tamargo J. Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. Eur J Pharmacol. 1993;232(1):105-111. DOI:10.1016/0014-2999(93)90734-y
94096-42-1 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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