Identification | Back Directory | [Name]
LU-43706 | [CAS]
94096-42-1 | [Synonyms]
LU-43706 (S)-Nafenodone Dexnafenodone HCl Dexnafenodone Hydrochloride | [Molecular Formula]
C20H24ClNO | [MOL File]
94096-42-1.mol | [Molecular Weight]
329.87 |
Hazard Information | Back Directory | [Description]
Dexnafenodone Hydrochloride, also known as LU-43706, is a dual of adrenergic receptor antagonist and serotonin uptake inhibitor potentially for the treatment of major depressive disorder. | [Uses]
Dexnafenodone hydrochloride ((S)-Nafenodone) as an antidepressant compound, is a potent and selective inhibitor of the synaptosomal uptake of noradrenaline, but has a less potent effect on serotonin uptake and a negligible effect on dopamine uptake. | [References]
[1] Pérez-Vizcaino F, Carrón R, Delpón E, Tamargo J. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. Eur J Pharmacol. 1991;199(1):43-50. DOI:10.1016/0014-2999(91)90635-4 [2] Pérez-Vizcaíno F, Carrón R, Delpón E, Duarte J, Tamargo J. Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. Eur J Pharmacol. 1993;232(1):105-111. DOI:10.1016/0014-2999(93)90734-y |
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