Identification | Back Directory | [Name]
(3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid | [CAS]
94159-47-4 | [Synonyms]
3-sucCA 3α-(3-Carboxy-1-oxopropoxy)-7α,12α-dihydroxy-5β-cholan-24-oic acid 3α-(3-Carboxypropionyloxy)-7α,12α-dihydroxy-5β-cholane-24-oic acid (3alpha,5beta,7alpha,12beta)-3-(3-carboxy-1-oxopropoxy)-7,12-dihydroxycholan-24-oic acid | [EINECS(EC#)]
303-227-6 | [Molecular Formula]
C28H44O8 | [MOL File]
94159-47-4.mol | [Molecular Weight]
508.644 |
Hazard Information | Back Directory | [Uses]
3-sucCA (3-Succinylated cholic acid) is a microbial derived bile acid. 3-sucCA is a lumen-restricted metabolite and alleviates alleviates MAFL-MASH progression in mouse models by reshaping the gut microbiota, especially by promoting the growth of Akkermansia muciniphila. 3-sucCA levels are lower in patients with biopsy-proven MAFLD[1]. | [References]
[1] Nie Q, et al. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell. 2024 May 23;187(11):2717-2734.e33. DOI:10.1016/j.cell.2024.03.034 |
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